Human MTHFR and MTRR gene polymorphism detection kit

Folic acid is a compound composed of pteridine, para-aminobenzoic acid and glutamic acid, and is a water-soluble B vitamin. Studies have found that folic acid is especially important for pregnant women, such as lack of folic acid within the first 3 months of pregnancy, can lead to fetal neural tube development defects, thereby increasing the incidence of split-brain and anencephaly. Excessive folic acid supplementation can increase the risk of colorectal cancer and breast cancer in pregnant women, develop allergic symptoms, affect the absorption of zinc, and lead to abnormal fetal development. Scientific research has confirmed that MTHFR and MTRR genes are closely related to folic acid metabolism, and the corresponding reduction in enzyme activity caused by these gene variants can inhibit the conversion of homocysteine ​​to methionine, resulting in hypofolate and hyperhomocysteine. acidemia, which increases the risk of neonatal birth defects or spontaneous miscarriage.

By detecting the polymorphisms of MTHFR (C677T, A1298C) and MTRR (A66G) genes, this kit determines the folic acid metabolism ability of the tested population, and assists doctors in the diagnosis and treatment of neonatal neural tube defects, gestational hypertension and other diseases during the perinatal period. The risk of morbidity is assessed to determine an individualized supplementation plan for folic acid.