Murine sarcoma viral oncogene homolog B1 (v-raf murine sarcoma viral oncogene homolog B1, B-raf) gene mutation mainly occurs in the V600 locus of exon 15, which plays an important role in tumor cell proliferation and differentiation. and apoptosis. A large number of clinical trials have proved that Vemurafenib has a significant effect on melanoma patients with B-raf gene mutation. B-raf gene mutation can lead to the low efficiency of lung cancer patients receiving EGFR-TKIs drug treatment, and some K-ras gene wild-type patients are not sensitive to EGFR monoclonal antibody treatment, which is also the diagnosis of papillary thyroid cancer (PTC) fine needle aspiration cytology specimens and an important indicator for the prognosis and diagnosis of the disease.
This kit detects the mutation of the V600E site of the B-raf gene, and provides a scientific basis for clinicians to select targeted drugs for individualized treatment.