Neuroblastoma ras viral oncogene homolog (Nras) is a member of the Ras gene family. In the signaling pathway of cells, Ras mainly activates kinases that control gene transcription and regulates cell proliferation and differentiation. . N-ras mutations mostly occur at codon 61, and the encoded amino acid is the action site of Ras protein and GTPase activating protein (GAP). Mutation of Nras results in a persistent activation of Ras-GTP, causing malignant cell proliferation and metastasis.
This kit detects 7 types of mutations (G12C, G12D, G12S, Q61R, Q61K, Q61L, Q61H) in codons 12 and 61 of N-ras gene, and is used to assist clinicians in screening who can benefit from cetuximab, paclitaxel Nituzumab in colorectal cancer patients.