The mouse sarcoma virus oncogene (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, K-ras) is a signal transduction protein located in the "downstream region" of the intracellular signal transduction pathway. When the gene is normal, it can control the regulation The path of cell growth inhibits the growth of tumor cells; when the gene is abnormal, it leads to disorder of intracellular signal transduction, uncontrolled cell proliferation and canceration.

This kit detects 7 types of mutations in codons 12 and 13 of K-ras gene exon 2 (GGT>GAT, GGT>GCT, GGT>GTT, GGT>AGT, GGT>CGT, GGT>TGT, GGC >GAC) to assist clinicians in screening colorectal cancer patients and non-small cell lung cancer patients who can benefit from targeted drugs.

Clinical studies have confirmed that the efficacy of targeted drugs is often related to the gene status of targeted molecular signaling pathways. The "2016 NCCN Guidelines for the Diagnosis and Treatment of Non-Small Cell Lung Cancer" clearly pointed out that if the K-ras gene is mutated, it is not recommended for patients to use gefitinib, erlotinib, etc. for molecular targeted therapy. "2016 NCCN Clinical Practice Guidelines for Colorectal Cancer" clearly states that all patients with metastatic colorectal cancer should be tested for K-ras gene status; only K-ras wild-type patients are recommended to receive EGFR inhibitors, such as cetuximab or panitumumab (either as a single agent or in combination with chemotherapy).

  Applicable models

ABI7300/7500/stepone/steponeplus/viia7、Cobas LC480、StrataGene Mx3005P/3000P、BioRad CFX96、SLAN-96S

This product has been approved by my country's CFDA

Registration certificate number: National Machinery Note 20183401955