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Human K-ras 7 mutations test kit

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Human K-ras 7 mutations test kit

Retail price
0.0
Market price
0.0
Number of views:
1000
Product serial number
Num:
HGN-kr01
Validity:
12 months
Specification:
12texts\kit
Sample Types:
paraffin-embedded tissue\Anticoagulated blood
Quantity
-
+
Stock:
1
Details

K-ras (K-ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is one of signal transduction downstream proteins intracellular. It can regulate the cell growth pathway and inhibit tumor cell proliferation, while it can lead to signal disorder intracellular and cancerization with the proliferation out of control when there is a mutation.

This kit can detect 7 mutations on 12&13 condon of exon 2 on K-ras(GGT>GAT、GGT>GCT、GGT>GTT、GGT>AGT、GGT>CGT、GGT>TGT、GGC>GAC), which could help clinician in screening colorectal cancer patients that may benefit from cetuximab and panitumumab. It could also help clinician to screen NSCLC patients may benefit from EGFR-TKIs like gefitinib, erlotinib and icotinib etc.

Clinical studies show that outcomes of target therapy are usually associated to the status of gene on the target signal pathway.

NCCN NSCLC clinical practice guideline suggests in 2016 that no molecular target therapy with gefitinib or erlotinib etc. is recomended when there is a mutation on K-ras, NCCN colorectal cancer clinical practice guideline suggests that all metastatic colorectal cancer patients should analyze K-ras status; only patients with K-ras wild type are recommended to take EGFR inhibitors like cetuximab or panitumumab (monotherapy or combination therapy).

Applicable Instruments

ABI7300/7500/stepone/steponeplus/viia7、

Cobas LC480、StrataGene Mx3005P/3000P、

BioRad CFX96、SLAN-96S

Product registration has been approved by CFDA

Registration number: 20183401955

  

20183401955

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